Long-term dysglycemia as a risk factor for faster cognitive decline during aging: A 12-year follow-up study

AbstractAims This longitudinal study evaluated associations between glucose metabolism and cognitive performance during a 12-year follow-up. Methods We included 714 subjects, which were followedfrom the age 55 to 70 years. Using oral tolerance tests population was classified as normoglycemic (NGT) based on WHO diagnostic criteria for diabetes prediabetes. Cognitive assessed with verbal fluency (category) test wordlist learning of CERAD-nb, (letter) test, trail-making A B. Results Compared normal group subjects long-lasting prediabetes showed significantly greater decline (4.6 versus 2.9 words) (p = 0.041); type 2 (13 6 s) trail making 0.021) (3.3 1.7 0.013); combined or incident (3.8 in 0.039). Conclusion Prediabetes associated aging. finding should be incorporated into prevention strategies, because both dementia are increasing world-wide.